MEK1/2 Antilichaam

The mitogen-activated protein kinase kinase 1 (MAP2K1, also known as MEK1) and the highly homologous MEK2 are members of the dual specificity protein kinase family (1) . MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals (2) . MEK1 lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, MEK1 is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development (2) .

5604

Q0VD16

NP_002746

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

MEK1/2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rabbit: (100%), Chicken: (87%)

MEK1/2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MEK1/2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

MEK1/2 antibody is human, mouse, and rat reactive. This antibody detects both MEK1 and MEK2.

MAP2K1

Mitogen-activated protein kinase kinase 1

Homo sapiens

Zheng CF and Guan KL. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J. Biol. Chem. 1993; 268:11435-9.

Marais R and Marshall CJ. Control of the ERK MAP kinase cascade by Ras and Raf. Cancer Surv. 1996; 27:101-25.

Mitogen-activated protein kinase kinase 1, MAP2K1, MAPKK1, MEK1, MKK1, PRKMK1, CFC3, Mitogen-activated protein kinase kinase 2, MAP2K2, MAPKK2, MEK2, MKK2, PRKMK2, CFC

ELISA, WB, IHC-P, IF

5579478

Liquid