Meldonium-d3

Meldonium-d3 is the deuterated form of Meldonium. Meldonium is a cardiovascular protective agent that competitively inhibits BBOX1 and OCTN2. The IC50 value of Mildronate against human recombinant BBOX is 34-62 μM, and the EC50 value against human OCTN2 is 21 μM. Meldonium is a fatty acid oxidation inhibitor[1][2][3].

MET-88-d3; Quaterin-d3

12352211

Isotope-Labeled Compounds; Mitochondrial Metabolism

Metabolic Enzyme/Protease; Others

Metabolic Disease; Cardiovascular Disease

O=C(CCN[N+](C)(C)C([2H])([2H])[2H])[O-]

C6H11D3N2O2

149.21

[1]Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113 (Pt B) :771-780.|[2]Jolanta Pupure, et al. Neuroprotective properties of mildronate, a mitochondria-targeted small molecule. Neurosci Lett. 2010 Feb 12;470 (2) :100-5.|[3]Daohui Wang, et al. Meldonium Ameliorates Hypoxia-Induced Lung Injury and Oxidative Stress by Regulating Platelet-Type Phosphofructokinase-Mediated Glycolysis. Front Pharmacol. 2022 Apr 5:13:863451.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B1836S/

Isotope-Labeled Compounds

No Development Reported