Meloxicam-13C6

Meloxicam-13C6 is 13C6-labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 μM and 36.6 μM for COX-2 and COX-1, respectively[1][2][3].

12352005

H301, H360, H412

Apoptosis; Autophagy; COX; Isotope-Labeled Compounds; MMP

Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; Others

Cancer; Inflammation/Immunology

98.93

O=C(C1=C(O)[13C]2=[13CH][13CH]=[13CH][13CH]=[13C]2S(N1C)(=O)=O)NC3=NC=C(C)S3

C8 13C6H13N3O4S2

357.36

H301, H360, H412

[1]Lazer ES, et al. Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity. J Med Chem. 1997 Mar 14;40 (6) :980-9. |[2]Iturriaga MP, et al. Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells. Oncol Lett. 2017 Aug;14 (2) :2198-2206.|[3]Fikry EM, et al. Rutin and meloxicam attenuate paw inflammation in mice: Affecting sorbitol dehydrogenase activity. J Biochem Mol Toxicol. 2018 Feb;32 (2) .

Blue Ice

-20°C, 3 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-B0261S4/

Isotope-Labeled Compounds

No Development Reported