Mequitazine

Mequitazine is a potent, and long-acting histamine H1 antagonist.

29216-28-2

LM-209

12352005

H301

Histamine Receptor

Reference compound

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

COVID-19-immunoregulation

Inflammation/Immunology; Endocrinology

https://www.medchemexpress.com/Mequitazine.html

99.99

DMSO : 50 mg/mL (ultrasonic)

C12=CC=CC=C1N(CC3CN4CCC3CC4)C5=C(C=CC=C5)S2

C20H22N2S

322.47

H301

[1]Gonnot V, et al. Expedient synthesis of mequitazine an antihistaminic drug by palladium catalyzed allylic alkylation of sodium phenothiazinate. Chem Pharm Bull (Tokyo) . 2009 Nov;57 (11) :1300-2.|[2]El-Nakeeb MA, et a. In vitro antibacterial activity of some antihistaminics belonging to different groups against multi-drug resistant clinical isolates. Braz J Microbiol. 2011 Jul;42 (3) :980-91.|[3]Martinez-Mir I, et al. Antihistaminic and anticholinergic activities of mequitazine in comparison with clemizole. J Pharm Pharmacol. 1988 Sep;40 (9) :655-6.|[4]Satake N, et al. Possible mechanisms of vasoinhibitory effects of mequitazine, an antiallergic agent, on the contractions of isolated rat aorta induced by K+, phenylephrine, 5-hydroxytryptamine, and Ca2+. J Cardiovasc Pharmacol. 1994 Apr;23 (4) :669-73.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-B2168/Mequitazine-SDS-MedChemExpress.pdf

Reference compound1

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