MER-antilichaam (7E5G1]

MER (c-mer proto-oncogene tyrosine kinase) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MER has been identified as a tyrosine kinase potentially involved in the development of glioblastomas. It is expressed at highest levels in ovary, prostate, lung and kidney. Gas6, a growth arrest specific gene, and the related anticoagulation factor Protein S have been identified as ligands for the UFO family of receptors. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP) .

10461

Q12866

Q12866

Human

Ni-NTA purified full-length recombinant MER-His expressed in E. Coli strain BL21 (DE3) .

7E5G1

Unconjugated

Primary Antibodies

Innate Immunity

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

MER monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

MERTK

C-mer proto-oncogene tyrosine kinase

Homo sapiens

McGough N. Cummings JH. Proc Nutr Soc.2005, Nov,64 (4) :434-50. Review.

Allouache D. Gawande SR. Tubiana-Hulin M. et al. BMC Cancer. 2005, Nov 29,5:151.

Seguineau C. Soudant P. Moal J. et al. Lipids.2005, Sep,40 (9) : 931-9.

MER, Proto-oncogene c-MerMER, RP38, c-mer

ELISA, WB

160332297