Merulidiaal

Merulidial (Compound 1) is an antibiotic and cytotoxic agent with a sesquiterpene dialdehyde structure. Merulidial significantly inhibits the germination of spores and the hyphal growth of the wood-roting basidiomycete Heterobasidion annosum (H. annosum) and the saprophytic mould Cladosporium cucumerinum (C.cucumerinum) . Merulidial also inhibits a variety of bacteria, algae and DNA synthesis of ECA cells. Merulidial shows a strong anticancer activity with IC50 s of 20 and 10 μg/mL for ECA and L1210 cells, respectively [1][2][3].

68053-32-7

(-) -Merulidial

12352211

Antibiotic; Bacterial; DNA/RNA Synthesis; Fungal

Anti-infection; Cell Cycle/DNA Damage

COVID-19-anti-virus

Cancer; Infection

O=C[C@@]12[C@@](C1)([C@H]([C@@]3([H])C(CC(C)(C3)C)=C2C=O)O)C

C15H20O3

248.32

[1]1. Svensson M, et al. Pyrone and pyridone compounds in the liquid culture of Physisporinus sanguinolentus. Phytochemistry. 2001 Apr; 56 (7) :747-51. |[2]2. Quack W, et al. Antibiotics from Basidiomycetes. V merulidial, a new antibiotic from the Basidiomycete Merulius tremellosus Fr. J Antibiot (Tokyo) . 1978 Aug; 31 (8) :737-41. |[3]3. Anke H, et al. Structure-activity relationships for unsaturated dialdehydes. 3. Mutagenic, antimicrobial, cytotoxic, and phytotoxic activities of merulidial derivatives. J Antibiot (Tokyo) . 1989 May; 42 (5) :738-44.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N15600/

Natural Products

No Development Reported