Meso-Tetra (4-pyridyl) porfine

Meso-Tetra (4-pyridyl) porphine (Compound 10) is a porphyrin derivative. meso-Tetra (4-pyridyl) porphine is a weak inhibitor of human topoisomerase I (Top1) with an EC50 value greater than 50 µM. meso-Tetra (4-pyridyl) porphine can be used in tumor research[1].

16834-13-2

12352005

H302, H315, H319, H335

Topoisomerase

Cell Cycle/DNA Damage

Cancer-programmed cell death

Cancer

97.0

C1(/C2=CC=NC=C2)=C3C=CC(/C(C4=CC=NC=C4)=C5C=C/C(N/5)=C(C6=CC=NC=C6)/C(C=C/7)=NC7=C(C8=CC=NC=C8)/C9=CC=C1N9)=N/3

C40H26N8

618.70

H302, H315, H319, H335

[1]Das SK, et al. Neutral Porphyrin Derivative Exerts Anticancer Activity by Targeting Cellular Topoisomerase I (Top1) and Promotes Apoptotic Cell Death without Stabilizing Top1-DNA Cleavage Complexes. J Med Chem. 2018 Feb 8;61 (3) :804-817.

Room Temperature

4°C (Powder, protect from light, stored under nitrogen)

http://file.medchemexpress.com/batch_PDF/HY-W008874/meso-Tetra-4-pyridyl-porphine-SDS-MedChemExpress.pdf

Reference compound2

No Development Reported