Meso-tetrafenylchlorine

Meso-tetraphenylchlorin (TPCS2a) is a photosensitizer with poor water solubility, which limits its use in the blood circulation. However, TPCS2a@NPs nanoparticles can be prepared based on polylactic-co-polyethylene glycol acid (PLGA) polymer core loaded with TPCS2. Such nanoparticles can be coated with mesenchymal stem cell-derived plasma membranes (mMSCs) to form mMSC-TPCS2a@NPs, which prolongs blood circulation time and improves tumor targeting ability. Compared with uncoated TPCS2a@NPs, mMSC-TPCS2a@NPs can reduce macrophage uptake by 54% to 70% under different conditions. Both nanoparticle forms are effectively accumulated in MCF7 and MDA-MB-231 breast cancer cells, while uptake in normal breast epithelial cells MCF10A is significantly lower[1].

2669-65-0

Fimaporfin (free base)

12352005

H302-H315-H319-H335

Photosensitizer

Apoptosis

Cancer-programmed cell death

Cancer

C1(/C(C(N2)=CC=C2/C(C3=CC=CC=C3)=C4CCC5=N\4)=C6C=CC(/C(C7=CC=CC=C7)=C(N/8)\CCC8=C5\C9=CC=CC=C9)=N/6)=CC=CC=C1

C44H34N4

618.77

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

[1]Mesenchymal Stem Cell Membrane-Coated TPCS2a-Loaded Nanoparticles for Breast Cancer Photodynamic Therapy

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W010713/

Reference compound1

No Development Reported