MET D1228N Recombinant humaan actief eiwit Kinase

Mesenchymal-to-epithelial transition (MET) is a receptor tyrosine kinase for hepatocyte growth factor (HGF) . MET overactivation is strongly associated with angiogenesis, cellular motility, growth, and invasion. Aberrant MET signaling can drive tumorigenesis in several cancer types through various molecular mechanisms, including MET amplification, MET exon 14 skipping mutation, MET overexpression, and MET fusions. MET D1228N is a mutant of MET. MET D1228N Recombinant Human Active Protein Kinase is a recombinant MET D1228N protein that can be used to study MET D1228N-related functions[1].

12352211

C-Met/HGFR

Protein Tyrosine Kinase/RTK

Cancer

[METD1228NRecombinantHumanActiveProteinKinase]

[1]Kang J, et al. Response and acquired resistance to MET inhibitors in de novo MET fusion-positive advanced non-small cell lung cancer. Lung Cancer. 2023 Apr;178:66-74.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-E70749/

Enzyme

No Development Reported