Methoxy-X04 (oplossing)

Methoxy-X04 (solution) is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques. Methoxy-X04 retains in vitro binding affinity for amyloid b (Ab) fibrils (Ki= 26.8 nM) . Methoxy-X04 is fluorescent and stains plaques, tangles, and cerebrovascular amyloid in postmortem sections of AD brain with good specificity[1][2].Solvent and concentration: DMSO: 5 mg/mL

863918-78-9

Amyloid-β

Neuronal Signaling

Neuroscience-Neurodegeneration

Neurological Disease

COC1=CC(/C=C/C2=CC=C(O)C=C2)=CC=C1/C=C/C3=CC=C(O)C=C3

C23H20O3

344.41

[1]Klunk WE, et al. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol. 2002 Sep;61 (9) :797-805.|[2]Bisht K, et al. Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques. J Vis Exp. 2016 Jun 1; (112) :54060.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-DY1045/

Dye Reagents

No Development Reported