Methylpyruvaat

Methyl pyruvate is a methyl ester derivative of pyruvic acid. Methyl pyruvate induces insulin release and membrane depolarization. Methyl pyruvate rescues proteasome damage and nuclear localization of TdP-43 caused by overexpression of σ1RE102Q by enhancing ATP synthesis. Methyl pyruvate selectively protects normal lung fibroblasts from cell death induced by Irinotecan. Methyl pyruvate promotes apoptosis and necrosis in cancer cells and downregulates angiogenesis and cell cycle pathways. Methyl pyruvate is an effective substrate for dihydrodihydrogen dehydrogenase.

600-22-6

12352211

H225

Apoptosis; ATP Synthase

Apoptosis; Membrane Transporter/Ion Channel

Cancer; Metabolic Disease

99.91

DMSO : 200 mg/mL (ultrasonic)

O=C(OC)C(=O)C

C4H6O3

102.09

H225

[1]Sato K, et al. Purification and characterization of dimeric dihydrodiol dehydrogenase from dog liver. J Biochem. 1994 Sep;116 (3) :711-7. |[2]Monchusi B, Ntwasa M. Methyl pyruvate protects a normal lung fibroblast cell line from irinotecan-induced cell death: Potential use as adjunctive to chemotherapy. PLoS One. 2017 Aug 10;12 (8) :e0182789.|[3]Tagashira H, et al. Methyl pyruvate rescues mitochondrial damage caused by SIGMAR1 mutation related to amyotrophic lateral sclerosis. Biochim Biophys Acta. 2014 Dec;1840 (12) :3320-34.|[4]Lembert N, et al. Methyl pyruvate initiates membrane depolarization and insulin release by metabolic factors other than ATP. Biochem J. 2001 Mar 1;354 (Pt 2) :345-50.

Room Temperature

Store at room temperature 3 years

http://file.medchemexpress.com/batch_PDF/HY-W012985/Methyl-pyruvate-SDS-MedChemExpress.pdf

Reference compound2

No Development Reported