Methylsuccinaat

Methyl succinate is a mitochondrial complex II substrate. Methyl succinate can bypass the inhibition of complex I by Metformin , restore mitochondrial electron transfer, and reduce AMPK phosphorylation. Methyl succinate is capable of protecting MIN6 β-cells and primary rat β-cells from biguanide-induced toxicity and apoptosis in vitro. Methyl succinate can be used in the research of diseases such as diabetes mellitus[1].

3878-55-5

12352211

H302, H315, H319, H335

AMPK; Apoptosis

Apoptosis; Epigenetics; PI3K/Akt/mTOR

Metabolic Disease

10mM

99.78

O=C(CCC(OC)=O)O

C5H8O4

132.11

H302, H315, H319, H335

[1]Hinke SA, et al. Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer. Br J Pharmacol. 2007 Apr;150 (8) :1031-43

Room Temperature

Store at room temperature 3 years

http://file.medchemexpress.com/batch_PDF/HY-W010380/

Natural Products

No Development Reported