MFSD2A Antilichaam

MFSD2A Antibody: Multidrug transporters, such as MFSD2A, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment and has recently been described as the human receptor for syncytin-2, a retrovirus-derived protein mediating fusion of placental trophoblasts. MFSD2A is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting. The activation of the betaAR signaling pathway plays a major role in the induction of MFSD2A expression during adaptive thermogenesis.

492810

Q5U3U7

NP_001129965

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

MFSD2A Antibody is affinity chromatography purified via peptide column.

Cat. No. 1462 - Rat Lung Tissue Lysate

1 mg/mL

MFSD2A Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MFSD2A antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

Mfsd2aa

Major facilitator superfamily domain containing 2aa

Danio rerio

Fluman N and Bibi E. Bacterial multidrug transport through the lens of the major facilitator superfamily. Biochim. Biophys. Acta.2009; 1794:738-47.

Law CJ, Maloney PC, and Wang DN. Ins and outs of major facilitator superfamily antiporters. Annu. Rev. Microbiol.2008; 62:289-305.

Spinola M, Falvella FS, Colombo F, et al. MFSD2A is a novel lung tumor suppressor gene modulating cell cycle and matrix attachment. Mol. Cancer2010;9:62.

Angers M, Uldry M, Kong D, et al. Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. Biochem. J.2008; 416:347-55.

MFSD2A Antibody: mfsd2a, zgc:101615, mfsd2a, Major facilitator superfamily domain-containing protein 2A-A

ELISA, WB, IHC-P, IF

55925395

Liquid