MGF24

MGF24 is a modified protease-resistant MGF derivative. MGF24 protects dopaminergic neurons from 6-Hydroxydopamine (6-OHDA) -induced apoptosis by inducing Heme oxygenase-1 (HO-1). MGF24 activates PKC-ε, which in turn activates Nrf2, up-regulating HO-1. MGF24 has neuroprotective activity and reduces myocardial infarct size in sheep models of myocardial ischemia. MGF24 can be used for neurological diseases like stroke, nerve injury and amyotrophic lateral sclerosis research[1].

1611488-66-4

12352209

Apoptosis; Drug Derivative; Heme Oxygenase (HO) ; Keap1-Nrf2; PKC

Apoptosis; Epigenetics; Metabolic Enzyme/Protease; NF-κB; Others; TGF-beta/Smad

Neurological Disease

O=C(N[C@@H](CCC(N)=O)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC5=CC=C(C=C5)O)N

C121H195N41O39

2848.09

[1]Quesada A, et al. C-terminal mechano-growth factor induces heme oxygenase-1-mediated neuroprotection of SH-SY5Y cells via the protein kinase Cϵ/Nrf2 pathway. J Neurosci Res. 2011 Mar;89 (3) :394-405.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11124/

Peptides

No Development Reported