MGMT Antilichaam - middengebied: FITC (ARP42038 P050-FITC)

O-6-methylguanine-DNA methyltransferase

4255

P16455

NP_002403

Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Yeast

The immunogen is a synthetic peptide directed towards the middle region of human MGMT

MGMT is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA.MGMT repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

UBC; BRCA2; ANXA2; ANXA1; SLC25A6; SLC25A4; ACTB; CCNB1; FBL; EEF1B2; EEF1A2; EEF1A1; DDX5; CDKN1A; CDK2; CDK1; H2BFM; FBXO27; TUBA1C; ANP32E; IL25; DDX24; CDK12; FBXO2; USP19; TUBB4B; PRPF4; RNF8; EIF3H; CDK10; HIST1H4A; HIST1H2AM; HIST3H3; SMC1A; YWHAZ

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 79%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

22kDa

Wet Ice

207

MGMT

MGMT

Rabbit

Methylated-DNA--protein-cysteine methyltransferase

NM_002412

ISYQQLAALAGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGG