MHES0488A
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
MHES0488A is a selective humanized antibody that targets HER2 with a KD value of 0.8 nM. MHES0488A is an antibody part of DHES0815A. MHES0488A is internalized by cells and transported to lysosomes, and then releases PBD-monoamide that enters the nucleus, alkylates DNA and induces DNA damage and apoptosis. MHES0488A is promising for research of cancers, such as HER2-positive breast cancer and gastric cancer[1].
DHES0815A antibody; RG-6148 antibody
12352203
DNA Alkylator/Crosslinker; EGFR
Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Cancer-Kinase/protease
Cancer
[MHES0488A]
[1]Lewis G, et al. Development of DHES0815A; a novel HER2-directed antibody-drug conjugate comprised of a reduced potency mono-alkylating agent linked to a domain I binding HER2 antibody[J]. 2022.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P991236/
Inhibitory Antibodies
No Development Reported
Beschrijving
MHES0488A is a selective humanized antibody that targets HER2 with a KD value of 0.8 nM. MHES0488A is an antibody part of DHES0815A. MHES0488A is internalized b
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