MIB1 Antilichaam

The E3 ubiquitin-protein ligase MIB1, also known as Mindbomb homolog 1, contains multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase (1) . MIB1 interacts with and regulates the cellular expression of the death-associated protein kinase 1 (DAPK1) protein by promoting its ubiquitination and degradation (1) . It also positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis (2) .

57534

Q86YT6

NP_065825

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis, Apoptosis

MIB1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1202 - A431 Cell Lysate

1 mg/mL

MIB1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MIB1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

MIB1 antibody is human, mouse and rat reactive. At least three isoforms of MIB1 are known to exist.

MIB1

Cat. No. 17-002 - A-431 Cell Slide

Mindbomb E3 ubiquitin protein ligase 1

Homo sapiens

Jin Y, Blue EK, Dixon S, et al. A death-associated protein kinase (DAPK) -interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular level of DAPK. J. Biol. Chem. 2002; 277:46980-6.

Hansson EM, Lanner F, Das D, et al. Control of Notch0ligand endocytosis by ligand-receptor interaction. J. Cell Sci. 2010; 123:2931-42.

MIB1 Antibody: MIB, DIP1, ZZZ6, DIP-1, LVNC7, ZZANK2, KIAA1323, E3 ubiquitin-protein ligase MIB1, DAPK-interacting protein 1

ELISA, WB, ICC, IF

30348954

Liquid