MIL62
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
MIL62 is a glycoengineered type II anti-CD20 monoclonal antibody with a nearly completely afucosylated N-glycans in Fc region. MIL62 shows enhanced affinity for the FcγRIIIa receptors and direct B-cell killing effects. MIL62 has antibody-dependent cell-mediated cytotoxicity (ADCC) activity. MIL62 can be used for the study of non-Hodgkin lymphoma (NHL) [1].
12352203
CD20
Immunology/Inflammation
Cancer-programmed cell death
Cancer
[1]Shi Y, et al. Efficacy and safety of MIL62, a novel glycoengineered type II anti-CD20 monoclonal antibody, combined with lenalidomide in patients with relapsed/refractory follicular lymphoma or marginal zone lymphoma: a multicentre, single-arm, phase 1b/2 trial. EClinicalMedicine. 2024 Jun 20;73:102702.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P991514/
Inhibitory Antibodies
No Development Reported
Beschrijving
MIL62 is a glycoengineered type II anti-CD20 monoclonal antibody with a nearly completely afucosylated N-glycans in Fc region. MIL62 shows enhanced affinity for
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