Miltiron (standaard)

Miltirone is an orally active natural compound found in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC50 of 0.3 μM. Miltirone induces ROS - and-p53 dependent apoptosis. Miltirone inhibits carboxylesterase 2 (CES2; Ki = 0.04 μM) and SARS-CoV main protease (Mpro) [1][2][3][4].

27210-57-7

Rosmariquinone (Standard)

12352005

Apoptosis; Carboxylesterase (CES) ; GABA Receptor; SARS-CoV

Anti-infection; Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Cancer; Neurological Disease

O=C1C(C(C)C)=CC2=C(C3=C(C=C2)C(C)(C)CCC3)C1=O

C19H22O2

282.38

[1]C M Lee, et al. Miltirone, a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia miltiorrhiza. Neurosci Lett. 1991 Jun 24;127 (2) :237-41.|[2]Wang L, et al. Miltirone induced mitochondrial dysfunction and ROS-dependent apoptosis in colon cancer cells. Life Sci. 2016 Apr 15;151:224-234.|[3]Hatfield MJ, et al. Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen") . J Nat Prod. 2013 Jan 25;76 (1) :36-44.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N1951R/

Reference Standards