Mimitin Antilichaam

Mimitin Antibody: Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC) . Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells. Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-κ B-related pathway. It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis. Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.

91942

Q8N183

NP_777549

Human

Unconjugated

Primary Antibodies

Cancer

Mimitin Antibody is affinity chromatography purified via peptide column.

Cat. No. 1207 - Raji Cell Lysate

1 mg/mL

Mimitin Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Mimitin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

NDUFAF2

Cat. No. 17-007 - Raji Cell Slide

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2

Homo sapiens

Tsuneoka M, Teye K, Arima M, et al. A novel Myc-target gene, mimitin, that is involved in cell proliferation of esophageal squamous cell carcinoma. J. Biol. Chem.2005; 280:19977-85.

Wegrzyn P, Yarwood SJ, Fiegler N, et al. Mimitin - a novel cytokine-regulated mitochondrial protein. BMC Cell Biol.2009; 10:23.

Ogilvie I, Kennaway NG, and Shoubridge EA. A molecular chaperone for mitochondrial complex I assembly is mutated in a progressive encephalopathy. J. Clin. Invest.2005; 115:2784-92.

Mimitin Antibody: MMTN, B17.2L, mimitin, NDUFA12L, Mimitin, mitochondrial, Myc-induced mitochondrial protein, MMTN

ELISA, WB, IF

29789409

Liquid