Minoxidil (hydrochloride)

Minoxidil (U10858) hydrochloride is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil hydrochloride is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].

69935-18-8

U10858 (hydrochloride)

12352005

Endogenous Metabolite; Potassium Channel

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Cardiovascular Disease

N=C1N=C(N2CCCCC2)C=C(N1O)N.Cl

C9H16ClN5O

245.71

[1]Hadjipavlou-Litina D, et al. Synthesis and evaluation of the antioxidative potential of minoxidil-polyamine conjugates. Biochimie. 2013 Jul;95 (7) :1437-49.|[2]Davies GC, et al. Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles. J Invest Dermatol. 2005 Apr;124 (4) :686-94. |[3]Cohen RL, et al. Direct effects of minoxidil on epidermal cells in culture. J Invest Dermatol. 1984 Jan;82 (1) :90-3.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0112A/

Reference compound1

No Development Reported