Mirvetuximab (poeder)

Mirvetuximab (M9346A) (powder) is an anti-FOLR1 (folate receptor 1) monoclonal antibody. Mirvetuximab (powder) is the antibody moiety of folate receptor alpha (FRα) -targeting ADC (Mirvetuximab soravtansine) . Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research[1][2][3].

1453084-36-0

M9346A (powder)

12352203

ADC Antibody; Antifolate

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Cancer

99.31

[Mirvetuximab(powder)]

(145.2 kDa)

[1]Moore KN, et al. Safety and Activity of Mirvetuximab Soravtansine (IMGN853), a Folate Receptor Alpha-Targeting Antibody-Drug Conjugate, in Platinum-Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer: A Phase I Expansion Study. J Clin Oncol. 2017 Apr 1;35 (10) :1112-1118.|[2]Loebrich S, et al. Development and Characterization of a Neutralizing Anti-idiotype Antibody Against Mirvetuximab for Analysis of Clinical Samples. AAPS J. 2017 Jul;19 (4) :1223-1234. |[3]Ab O, et al. IMGN853, a Folate Receptor-α (FRα) -Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors. Mol Cancer Ther. 2015 Jul;14 (7) :1605-13.

Dry Ice

Store at -80°C for 2 years

http://file.medchemexpress.com/batch_PDF/HY-P99225A/Mirvetuximab-powder-SDS-MedChemExpress.pdf

Inhibitory Antibodies

No Development Reported