Mirzotamab clezutoclax
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Mirzotamab clezutoclax (ABBV-155) is a first-in-class antibody-drug conjugate (ADC) with three components: an anti-B7-H3 monoclonal antibody, and BCL2L1 (BCL-XL) inhibitor Clezutoclaxum. Mirzotamab clezutoclax can be used for the study of relapsed and/or refractory (R/R) solid tumors[1].
2229859-12-3
ABBV-155
12352100
Antibody-Drug Conjugates (ADCs) ; Bcl-2 Family; CD276/B7-H3
Antibody-drug Conjugate/ADC Related; Apoptosis; Immunology/Inflammation
Cancer-programmed cell death
Cancer
10 mM in DMSO
[Mirzotamabclezutoclax]
[1]Tolcher A W, et al. A first-in-human study of mirzotamab clezutoclax as monotherapy and in combination with taxane therapy in relapsed/refractory solid tumors: Dose escalation results. 2021.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P99741/
Inhibitory Antibodies
No Development Reported
Bcl-xL
Beschrijving
Mirzotamab clezutoclax (ABBV-155) is a first-in-class antibody-drug conjugate (ADC) with three components: an anti-B7-H3 monoclonal antibody, and BCL2L1 (BCL-XL
Specificaties
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