MITF Antilichaam - middengebied: Biotine (ARP37978 P050-Biotine)

Microphthalmia-associated transcription factor

MI, WS2, CMM8, WS2A, COMMAD, bHLHe32

4286

O75030-9

NP_000239

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human MITF

MITF is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

EBP; STUB1; HK3; EPAS1; LEF1; APP; HINT1; ELAVL1; CDK2; SUMO2; PSMD14; MARK3; PIAS3; PIAS2; PIAS1; SUMO1; UBE2I; PAX3; OTX2; PAX6; PATZ1; GSK3B; TFEC; EP300; RPS6KA1; TFEB; MAPK14; TFE3; MAPK1; SPI1; FOS; CTNNB1; CDKN1A; RB1

Biotin

Polyclonal Antibody

WB

Affinity Purified

MITF is supported by BioGPS gene expression data to be expressed in HeLa

0.5 mg/ml

Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

47kDa

Chiaverini, C., (2008) J. Biol. Chem. 283 (18), 12635-12642

Wet Ice

419

MITF

MITF

Rabbit

Microphthalmia-associated transcription factor

NM_000248

MGSKLEDILMDDTLSPVGVTDPLLSSVSPGASKTSSRRSSMSMEETEHTC