Mivebresib (ABBV-075)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
1445993-26-9
C13393-5mg
Epigenetic Reader Domain
Epigenetics
CCS (=O) (=O) NC1=CC (=C (C=C1) OC2=C (C=C (C=C2) F) F) C3=CN (C (=O) C4=C3C=CN4) C
C22H19F2N3O4S
Mivebresib (ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4), but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM) and has moderate activity towards CREBBP (Kd = 87 μM; 54-fold selectivity vs. BRD4) . Mivebresib (ABBV-075) efficiently triggers apoptosis in various tumor cell.
2 years -80 in solvent
Beschrijving
Mivebresib (ABBV-075) Beschikbaar in 5 mg. Wordt geleverd met droogijs. Bestel eenvoudig online met snelle levering.
Specificaties
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