MK-1248
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
MK-1248 is a human IgG4 monoclonal antibody (mAb) targeting TNFSF18. MK-1248 enhances the proliferative response of tumor-infiltrating lymphocytes to anti-CD3 stimulation and promotes the production of anti-tumor-associated regulatory cytokines. MK-1248 can be used in solid tumors research[1].
12352203
TNF Receptor
Apoptosis
Cancer-programmed cell death
Cancer
[MK-1248]
[1]Geva R, et al. First-in-human phase 1 study of MK-1248, an anti-glucocorticoid-induced tumor necrosis factor receptor agonist monoclonal antibody, as monotherapy or with pembrolizumab in patients with advanced solid tumors. Cancer. 2020 Nov 15;126 (22) :4926-4935.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P991406/
Inhibitory Antibodies
No Development Reported
TNFRSF18/GITR/CD357
Beschrijving
MK-1248 is a human IgG4 monoclonal antibody (mAb) targeting TNFSF18. MK-1248 enhances the proliferative response of tumor-infiltrating lymphocytes to anti-CD3 s
Specificaties
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