MK-2748
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
MK-2748 is a hepatitis C virus (HCV) NS3/4a protease inhibitor. MK-2748 exhibits broad-spectrum and potent antiviral activity, with nanomolar-level activity against all genotypes (gt1a-gt6) (IC₅₀ IC₅₀ = 0.032 nM) and D168Y (IC₅₀ = 0.057 nM) . MK-2748 can be used in the research of HCV infection[1].
1193902-95-2
12352005
HCV; HCV Protease
Anti-infection; Metabolic Enzyme/Protease
Infection
O=C([C@H](C[C@](OC(N1CCCCC[C@@]2([H])[C@](CCC2)([H])O3)=NC4=CC(OC)=CC=C4C1=O)([H])C5)N5C([C@H](C6CCCC6)NC3=O)=O)N[C@]7([C@H](C=C)C7)C(NS(=O)(C8(CC8)C)=O)=O
C42H56N6O10S
836.99
[1]Rudd MT, et al. P2-quinazolinones and bis-macrocycles as new templates for next-generation hepatitis C virus NS3/4a protease inhibitors: discovery of MK-2748 and MK-6325. ChemMedChem. 2015 Apr;10 (4) :727-35.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-19932/
Reference compound1
No Development Reported
Beschrijving
MK-2748 is a hepatitis C virus (HCV) NS3/4a protease inhibitor. MK-2748 exhibits broad-spectrum and potent antiviral activity, with nanomolar-level activity aga
Specificaties
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