MK-7725

MK-7725 is a selective, orally active, and blood-brain barrier-permeable agonist of the subtype 3 of the frog skin peptide receptor (BRS-3) . MK-7725 has a high affinity for the human BRS-3 (hBRS-3), with an IC50 of 3 nM, and its functional activity in the mouse-derived BRS-3 (mBRS-3) model with an EC50 of 22 nM (105% agonistic) . MK-7725 significantly reduces the body weight of obese rats and obese dogs. MK-7725 can be used for the treatment of obesity[1].

1034152-93-6

12352005

Bombesin Receptor

GPCR/G Protein

Metabolism-protein/nucleotide metabolism

Metabolic Disease

O=S(N1C2=C(C3=NOC(C(C)(O)C)=N3)C=CC=C2NC4=NC(C(F)(F)F)=CC=C4C1)(C5=CC=C(OC(F)(F)F)C=C5)=O

C25H19F6N5O5S

615.50

[1]Chobanian HR, et al. Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity. ACS Med Chem Lett. 2012 Jan 21;3 (3) :252-6.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-18612/

Reference compound1

No Development Reported