MKK3 (Ab 189) Antilichaam

MEK3 belongs to MAPKK family. This kinase is activated by mitogenic and environmental stress, and participates in the MAPK-mediated signaling cascade. It phosphorylates and thus activates p38. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of Ras oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of p38, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis.

5606

P46734

NP_002747.2

Human, Mouse, Rat

MKK3 (Ab-189) antibody was raised against a peptide sequence around aa.187~191 (V-D-S-V-A) derived from Human MKK3.

Unconjugated

Primary Antibodies

Other

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

40 kDa

This antibody detects endogenous level of total MKK3 protein.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

MAP2K3

Mitogen-activated protein kinase kinase 3

Homo sapiens

Wang W, et al. (2002) Mol Cell Biol ; 22 (10) : 3389-403. Raingeaud J, et al. (1996) Mol Cell Biol; 16 (3) : 1247-55.

MEK3, MKK3, MAPKK3, PRKMK3, SAPKK2, SAPKK-2, ERK1, PRKM3, MAP kinase kinase 3, MAP2K3, MAPK/ERK kinase 3, MAPKK 3, MEK3

WB, IHC, IF

21618347

Liquid