MKK6 (Ab 207) Antilichaam

MEK6 is a member of MAPKK protein kinase family. By using degenerate oligonucleotide primers from the conserved kinase domains of MKK3 and MKK4 two human cDNAs and 1 murine cDNA encoding closely related proteins of the MKK family were cloned. The two human clones appear to be different isoforms of the same gene generated by differential splicing: the shorter clone was designated MKK6, encodes a 278-amino acid protein, while the longer clone, designated MKK6b, encodes a 334-amino acid protein. MKK6 is about 80% identical to MKK3 and 40% identical to MKK4. 1.7-kb human MKK6 transcript is highly expressed in skeletal muscle, while an MKK6b-specific probe detected mRNA bands of 1.8, 2.4, and 4.5 kb that are enriched in heart, skeletal muscle, pancreas and liver. MKK6 plays an important role in intracellular signaling pathways leading toward activation of the p38 MAP kinase . MEK6 phosphorylates and activates p38 in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAPK mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.

5608

P52564

NP_002749.2

Human

MKK6 (Ab-207) antibody was raised against a peptide sequence around aa.205~209 (V-D-S-V-A) derived from Human MKK6.

Unconjugated

Primary Antibodies

Other

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

41 kDa

This antibody detects endogenous level of total MKK6 protein.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

MAP2K6

Mitogen-activated protein kinase kinase 6

Homo sapiens

Wang W, et al. (2002) Mol Cell Biol ; 22 (10) : 3389-403. Raingeaud J, et al. (1996) Mol Cell Biol; 16 (3) : 1247-55.

MEK6, MKK6, MAPKK6, PRKMK6, SAPKK3, SAPKK-3, CCNE, MAP kinase kinase 6, MAP2K6, MAPK/ERK kinase 6, MAPKK 6, MEK6

WB, IHC, IF

14589900

Liquid