MKRN3 Antilichaam

The Makorin ring finger 3 (MKRN3) protein contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. The MKRN3 gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome (1), but a deletion of the gene does not (2) . A deficiency of MKRN3 has been shown to cause central precocious puberty in humans (3) .

7681

Q6NSB6

NP_005655

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

MKRN3 antibody is affinity chromatography purified via peptide column.

Cat. No. 1306 - Human Spleen Tissue Lysate

1 mg/mL

MKRN3 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MKRN3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

MKRN3 antibody is human specific. MKRN3 antibody is predicted to not cross-react with other members of the MKRN protein family.

MKRN3

Cat. No. 10-901 - Human Spleen Tissue Slide

Makorin ring finger protein 3

Homo sapiens

Jong MT, Gray TA, Ji Y, et al. A novel imprinted gene, encoding a RING zinc-finger protein, a overlapping antisense transcript in the Prader-Willi syndrome critical region. Hum. Mol. Genet. 1999; 8:783-93.

Kanber D, Giltay J, Wieczorek D, et al. A paternal deletion of MKRN3, MAGEL2 and NDN does not result in Prader-Willi syndrome. Eur. J. Hum. Genet. 2009; 17:582-90.

Abreu AP, Dauber A, Macedo DB, et al. Central precocious puberty caused by mutations in the imprinting gene MKRN3. N. Engl. J. Med. 2013; 368:2467-75.

Makorin ring finger 3, CPPB2, D15S9, RNF63, ZFP127, ZNF127

ELISA, WB, IF

5032243

Liquid