ML-10

ML-10 is a small molecule apoptosis probe. Due to the presence of fluorine atoms, ML-10 can be radiolabeled with 18F isotopes and can be used for apoptosis positron emission tomography imaging studies. ML-10 is selectively taken up and accumulated in apoptotic cells, while being excluded from live or necrotic cells. In addition, the uptake of ML-10 is associated with apoptotic features such as caspase activation, Annexin-V binding, and disruption of mitochondrial membrane potential[1].

1216897-16-3

12352211

H302, H315, H319, H335

Apoptosis

Apoptosis

Cancer; Cardiovascular Disease

95.0

O=C(O)C(C)(CCCCCF)C(O)=O

C9H15FO4

206.21

H302, H315, H319, H335

[1]Cohen A, et al. From the Gla domain to a novel small-molecule detector of apoptosis. Cell Res. 2009 May;19 (5) :625-37.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-76573/ML-10-SDS-MedChemExpress.pdf

Reference compound1

Phase 2