ML239
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
A novel inhibitor of the growth and proliferation of breast cancer stem cells (CSC) discovered in a phenotypic screen employing CSC-like cells produced by inducing human breast epithelial cells into an epithelial-to-mesenchymal transdifferentiated state (HMLE_sh_ECad) . ML239 displayed an IC50=1.18 μM against HMLE_sh_ECad and demonstrated a >23-fold selectivity over control cells. It was also toxic to two other CSC-like lines1,2. Gene expression studies showed altered gene expression in the NFκB pathway1 and support activation of fatty acid desaturase 2 (FADS2) as a potential mechanism of action for ML239.3
Unconjugated
Beige solid
-20°C
Beschrijving
ML239 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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