ML792
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
ML792 is a potent (IC50’s = 3 nM SUMO1; 11 nM SUMO2) and selective (IC50 = 32 µM for NEDD8-activating enzyme (NAE) ) mechanism-based inhibitor of SUMO-activating enzyme (SAE) .1 Treatment of multiple cancer cell lines led to failure of mitotic progression and induction of endoreduplication with MYC-amplified cell lines showing higher sensitivity. ML792 inhibited B-cell growth and promoted cell death in Epstein-Barr virus (EBV) -positive B cells and nasopharyngeal carcinoma cells. It also modulated Latent Membrane Protein-1-induced cell migration and cell adhesion suggesting therapeutic potential in treating EBV-associated malignancies.2
Unconjugated
White solid
-20°C
Beschrijving
ML792 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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