MLF1 Antilichaam - N-terminalgebied: Biotine (ARP53757 P050-Biotine)

Myeloid leukemia factor 1

4291

P58340

NP_071888

Human, Mouse, Rat, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human MLF1

MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. It interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. MLF1 suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest.It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

CENPU; COPS3; UBC; NRBP1; YWHAZ; GRIK5; MAGEA11

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Human: 100%; Mouse: 79%; Rabbit: 90%; Rat: 79%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

29kDa

Li, Z.F., J. Neurol. Sci. 264 (1-2), 77-86 (2008)

Wet Ice

268

MLF1

MLF1

Rabbit

Myeloid leukemia factor 1

NM_022443

GRDLLSISDGRGRAHNRRGHNDGEDSLTHTDVSSFQTMDQMVSNMRNYMQ