MLH1 Mouse Monoclonal Antibody [Kloon ID: LBI4H4]

The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . [provided by RefSeq, Aug 2017]

Carrier-free (BSA/glycerol-free) MLH1 mouse monoclonal antibody, clone LBI4H4

COCA2; FCC2; hMLH1; HNPCC; HNPCC2; MMRCS1

Homo sapiens mutL homolog 1 (MLH1), transcript variant 1, mRNA.

4292

P40692

Unconjugated

Colorectal cancer, Endometrial cancer, Mismatch repair, Pathways in cancer

Colorectal cancer, Endometrial cancer, Mismatch repair, Pathways in cancer

IHC 1:1000

Druggable Genome

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

MLH1

https://www.ncbi.nlm.nih.gov/gene/?term=4292

https://www.uniprot.org/uniprot/P40692