MLK1/2 (fosfo Thr312/266) Antilichaam

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.

4293;4294

P80192; Q02779

NP_001271159.1

Human, Mouse

MLK1/2 (phospho Thr312/266) antibody was raised against a peptide sequence around phosphorylation site of threonine 312/266 (A-G-T (p) -Y-A) derived from Human MLK1/2.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20&#730, C for up to one year.

121 kDa

IgG

The antibody detects endogenous levels of MLK1/2 only when phosphorylated at threonine 312/266.

MAP3K9, MAP3K10

Mitogen-activated protein kinase kinase kinase 9, mitogen-activated protein kinase kinase kinase 10

Homo sapiens

Durkin J.T., Biochemistry 43:16348-16355 (2004) .

The MGC Project Team, Genome Res. 14:2121-2127 (2004) .

Dorow D.S., Nature 446:153-158 (2007) .

M3K9, PRKE1, mixed-lineage protein kinase 1

IHC

52421790

Liquid