MLL Antibody10F8D7

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) .Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle, that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein, also designated MEN) functions as an RNA polymerase II elongation factor that increases the rateof transcription by suppressing transient pausing by RNA polymerase II. Also, ELL is thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, and has lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary.The gene encoding human ELL, which maps to chromosome 19p13.1, is one of several genes which undergo translocation with the MLL gene on chromo-some 11q23 in acute myeloid leukemia. MLL (myeloid/lymphoid leukemia, also designated ALL-1 and HRX) is a 430 kDa protein that regulates embryonal and hematopoietic development.

4297

Q03164

Q03164

Human

Purified truncated recombinant MLL-Trx (aa3751-3968) is expressed in E.Coli strain BL21 (DE3) .

10F8D7

Unconjugated

Primary Antibodies

Other

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

MLL monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

KMT2A

Lysine (K) -specific methyltransferase 2A

Homo sapiens

Genet Couns. 2006;17 (2) :155-9.

Cancer Genet Cytogenet. 2006 Jul 15;168 (2) :162-7.

Leukemia. 2007 Feb;21 (2) :360-2. Epub 2007 Jan 4.

ALL1, CXXC7, HRX, HTRX, MLL, MLL1, TRX1, ALL-1, Lysine N-methyltransferase 2A, HTRX1, MLL1A, WDSTS, MLL/GAS7, TET1-MLL

WB, IHC

146345435