MLLT11 (NM 006818) Humaan Recombinant eiwit

The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t (1;11) (q21; q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]

Purified recombinant protein of Human myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), translocated to, 11 (MLLT11), full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

AF1Q

10962

Q13015, Q6FGF7

NM_006818

1q21.3

E. coli

N-GST and C-His

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

37.9 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

MLLT11

Human

NP_006809

https://www.ncbi.nlm.nih.gov/gene/10962

https://www.uniprot.org/uniprot/Q13015

https://www.ncbi.nlm.nih.gov/nuccore/NM_006818

https://www.ncbi.nlm.nih.gov/nuccore/NP_006809