MLXIP-antilichaam

MLXIP Antibody: MLXIP is a member of the Myc superfamily of transcription factors and functions as part of a heterodimer with Max-like protein X (MLX) to activate transcription (1) . MLXIP contributes to the regulation of glucose homeostasis as the MLXIP/MLX heterodimer activates expression of thioredoxin-interacting protein (TXNIP), a potent inhibitor of cellular glucose uptake and aerobic glycolysis. The mammalian target of rapamycin (mTOR) suppresses the activation of the TXNIP pathway by binding to MLXIP, thereby preventing the MLXIP/MLX heterodimer formation (2) . MLXIP interaction with Myc may also be involved in metabolic reprogramming and tumorigenesis (3) .

22877

Q9HAP2

NP_055753

Human

MLXIP antibody was raised against a peptide corresponding to 19 amino acids near the amino terminus of human MLXIP.

Unconjugated

Primary Antibodies

Homeostasis

MLXIP Antibody is affinity chromatography purified via peptide column.

Cat. No. 1219 - MCF7 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (95%)

MLXIP Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MLXIP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

MLXIP

MLX interacting protein

Homo sapiens

Billin AN, Eilers AL, Coulter KL, et al. MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. Mol. Cell Biol. 2000; 20:8845-54.

Kaadige MR, Yang J, Wilde BR, et al. MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction. Mol. Cell Biol. 2015; 35:101-10.

Carroll PA, Diolaiti D, McFerrin L, et al. Deregulated Myc requires ModoA/Mlx for metabolic reprogramming and tumorigenesis. Cancer Cell 2015; 27:271-85.

MLXIP Antibody: FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E

ELISA, WB

111955326

Liquid