MM-111
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
MM-111 is a bispecific antibody fusion protein targeting the ErbB2/ErbB3 oncogenic unit. MM-111 blocks activation of the PI3K pro-survival pathway. MM-111 binds to the ErbB2 receptor, which localizes the bispecific molecule to ErbB2 over-expressing tumor cells and promotes binding of the anti-ErbB3 arm to the ErbB3 receptor. MM-111 binding to ErbB3 results in inhibition of ErbB3 signaling by blocking the binding of the ErbB3 physiological ligand heregulin. MM-111 can be used for the study of ErbB2 over-expressing breast tumors[1].
1361108-53-3
12352203
EGFR
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Cancer-Kinase/protease
Cancer
[1]Alexandra Huhalov, et al. Abstract 3485: MM-111, an ErbB2/ErbB3 bispecific antibody with potent activity in ErbB2-overexpressing cells, positively combines with trastuzumab to inhibit growth of breast cancer cells driven by the ErbB2/ErbB3 oncogenic unit. Cancer Res (2010) 70 (8_Supplement) : 3485.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P991524/
Inhibitory Antibodies
No Development Reported
Beschrijving
MM-111 is a bispecific antibody fusion protein targeting the ErbB2/ErbB3 oncogenic unit. MM-111 blocks activation of the PI3K pro-survival pathway. MM-111 binds
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