MMF2 Antilichaam

Mitofusin 2 (MFN2) and the related protein MFN1 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (1,2) . MFN2 is ubiquitously expressed, and found in both the ER and outer mitochondrial membrane. MFN2 has two key domains: a coiled coil region that mediates MFN2 binding and a GTPase domain that likely plays a role in fusion (3,4) . Both domains are essential for embryonic development and may play a role in the pathobiology of obesity. Overexpression of MFN2 causes mitochondrial dysfunction and cell death (5) .

9927

O95140

NP_055689

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Obesity, Apoptosis

MFN2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

MFN2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

MFN2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

MFN2 antibody is human, mouse and rat reactive. At least three isoforms of MFN2 are known to exist. MFN2 antibody is predicted to not cross-react with MFN1.

MFN2

Mitofusin 2

Homo sapiens

Chen H, Detmer SA, Ewald AJ, et al. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J. Cell Biol. 2003; 160:189-200.

Ishihara N, Eura Y, and Mihara K. Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity. J. Cell Sci. 2004; 117:6535-46.

Bach D, Pich S, Soriano FX, et al. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J. Biol. Chem. 2003; 278:17190-7.

Renaldo F, Amati-Bonneau P, Slama A, et al. MFN2, a new gene responsible for mitochondrial DNA depletion. Brain 2012; 135:e223, 1-4.

MFN2 Antibody: HSG, MARF, CMT2A, CPRP1, CMT2A2, KIAA0214, Mitofusin-2, Transmembrane GTPase MFN2

ELISA, WB, IHC-P, IF

7662004

Liquid