MMP-2 Recombinant eiwit

Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-2 is a secreted collagenase with specificity toward Type IV, V, VII, and X collagens. Recombinant human MMP-2 is a 62.0 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (552 amino acids) .

4313

P08253

NP_004521.1

Recombinant Proteins

E. coli

Cancer, Cell Cycle, Obesity, Other

Room Temp

The lyophilized MMP-2 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted MMP-2 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing MMP-2 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

Homo sapiens

CLG4, MONA, CLG4A, TBE-1, MMP-II, 72 kDa type IV collagenase, 72 kDa gelatinase, MMP-2

Human

11342666

Lyophilized