MMP-3 Recombinant eiwit

Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-3 degrades fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids) .

4314

P08254

NP_002413.1

Recombinant Proteins

E. coli

Cancer, Cell Cycle, Signal Transduction, Other

Room Temp

The lyophilized MMP-3 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted MMP-3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing MMP-3 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Matrix metallopeptidase 3 (stromelysin 1, progelatinase)

Homo sapiens

SL-1, STMY, STR1, CHDS6, MMP-3, STMY1, Stromelysin-1, Matrix metalloproteinase-3, SL-1

Human

4505217

Lyophilized