MMP1 Antilichaam - C-terminaal gebied: Biotine (ARP42040 T100-Biotine)

Matrix metallopeptidase 1 (interstitial collagenase)

CLG, CLGN

4312

P03956

NP_002412

Human, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the C terminal region of human MMP1

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP1 is a secreted enzyme which breaks down the interstitial collagens, types I, II, and III.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

SOX8; UBC; TNFSF11; CCL13; BCAN; TIMP1; ITGA2; MMP7; CCL7; CCL2; ACAN; TFPI; IGFBP3; COL2A1; CMA1; BSG; SERPINA3; CD44; F2R

Biotin

Polyclonal Antibody

IHC, WB

MMP1 is supported by BioGPS gene expression data to be expressed in HT1080

0.5 mg/ml

Cow: 93%; Dog: 79%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Rabbit: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

52kDa

Montero, I., (2006) J. Am. Coll. Cardiol. 47 (7), 1369-1378

Wet Ice

469

MMP1

MMP1

Rabbit

Interstitial collagenase

NM_002421

YPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKA