MNLS-CPP-WSTF (TFA)

MNLS-CPP-WSTF TFA is the trifluoroacetate salt of mNLS-CPP-WSTF. mNLS-CPP-WSTF is a nuclear localization signal (NLS) -cell-penetrating peptide based on the mouse WSTF sequence. mNLS-CPP-WSTF significantly inhibits the GABARAP-WSTF interaction, WSTF degradation and inflammatory gene expression. mNLS-CPP-WSTF effectively attenuates chronic inflammation, liver fibrosis and cartilage damage in metabolic-dysfunction-associated steatohepatitis (MASH) and osteoarthritis (OA) mice model. mNLS-CPP-WSTF is promising for research of chronic inflammatory diseases such as MASH and OA[1].

12352209

GABA Receptor

Membrane Transporter/Ion Channel; Neuronal Signaling

Inflammation/Immunology

96.20

O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CC(C)C)C(N4[C@@H](CCC4)C(N5[C@@H](CCC5)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H](CC7=CC=C(C=C7)O)C(N[C@@H](CC8=CC=C(C=C8)O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N.OC(C(F)(F)F)=O.[x]

C219H361N69O64.xC2HF3O2

4984.63 (free base)

[1]Wang Y, et al. WSTF nuclear autophagy regulates chronic but not acute inflammation. Nature. 2025 Jul 2.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P11208C/mNLS-CPP-WSTF-TFA-SDS-MedChemExpress.pdf

Peptides

No Development Reported