Moroxydine (hydrochloride) -d8

Moroxydine hydrochloride-d8 (ABOB hydrochloride-d8) is the deuterium labeled Moroxydine (ABOB) hydrochloride. Moroxydine hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels[1][2][3].

2469734-82-3

ABOB hydrochloride-d8

12352005

Apoptosis; Caspase; HCV; HSV; Influenza Virus; Isotope-Labeled Compounds

Anti-infection; Apoptosis; Others

COVID-19-anti-virus

Infection

N=C(N1C([2H])(C([2H])(OC([2H])(C1([2H])[2H])[2H])[2H])[2H])NC(N)=N.Cl

C6H6D8ClN5O

215.71

[1]Yu XB, et al. Moroxydine (ABOB) hydrochloride hydrochloride inhibits grass carp reovirus replication and suppresses apoptosis in Ctenopharyngodon idella kidney cells. Antiviral Res. 2016 Jul;131:156-65. |[2]Yu XB, et al. In vitro antiviral efficacy of Moroxydine (ABOB) hydrochloride hydrochloride and ribavirin against grass carp reovirus and giant salamander iridovirus. Dis Aquat Organ. 2016 Oct 27;121 (3) :189-199. |[3]Yu XB, et al. Effects of Moroxydine (ABOB) hydrochloride hydrochloride and ribavirin on the cellular growth and immune responses by inhibition of GCRV proliferation. Res Vet Sci. 2018 Apr;117:37-44.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W713297/

Isotope-Labeled Compounds

No Development Reported