Motolimod
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Motolimod (926927-61-9) is a selective Toll-like receptor 8 (TLR8) agonist (EC50 = 100 nM) . It stimulates the production of TNFα and IL-12 from monocytes and myeloid dendritic cells. Motolimod also stimulated IFNγ production from NK cells and increased their toxicity against K562 and ADCC by rituximab and trastuzumab.1,2 It induced apoptosis in monocytic myeloid-derived suppressor cells.3 Motolimod is being investigated in combination with other cancer immunotherapies.4,5 Motolimod has also been shown in induce secreted IL-1b and IL-8 via activation of the NLRP3 inflammasome.6
Unconjugated
Off-white or pale yellow solid
-20°C
Beschrijving
Motolimod Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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Oxidative Stress Combo Assay Blood Kit
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100 µL