Mouse Serum Albumine

Mouse Serum Albumin is most abundant protein in plasma, which leaks into the brain parenchyma when the blood-brain barrier (BBB) is impaired. Mouse Serum Albumin induces astrocytes to A1 phenotype to remarkably increase levels of Elovl1. Mouse Serum Albumin promotes VLSFAs secretion and causes neuronal lippoapoptosis through endoplasmic reticulum stress response pathway. MSA-activated microglia triggeres remarkable tau phosphorylation at multiple sites (Ser202/Thr205) through NLRP3 inflammasome pathway. Mouse Serum Albumin decreases the spatial learning and memory abilities in mice. Mouse Serum Albumin can be used for the study of neurodegenerative diseases like Alzheimer’s disease (AD) and frontotemporal dementia (FTD) [1].

12352005

Apoptosis; Caspase; ELOVL; NOD-like Receptor (NLR) ; Tau Protein

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling

COVID-19-immunoregulation

Inflammation/Immunology; Neurological Disease

[MouseSerumAlbumin]

[1]Hou SJ, et al. Mouse serum albumin induces neuronal apoptosis and tauopathies. Acta Neuropathol Commun. 2024 Apr 23;12 (1) :66.

Blue Ice

Store at -20°C for 2 years

http://file.medchemexpress.com/batch_PDF/HY-NP0204/Mouse-Serum-Albumin-SDS-MedChemExpress.pdf

Biochemical Assay Reagents

No Development Reported