MP-RM-1
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
MP-RM-1 is a selective murine monoclonal antibody inhibitor targeting human epidermal growth factor receptor 3 (ErbB-3) . MP-RM-1 blocks the activation of ErbB-3 induced by neuregulin 1 (NRG-1β) and promotes the internalization and degradation of ErbB-3, inhibiting downstream signaling pathways such as PI3K-Akt. MP-RM-1 is promising for research of ErbB-3 highly expressed solid tumors such as breast cancer, melanoma, and prostate cancer[1].
12352203
Akt; EGFR; PI3K
JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Cancer-Kinase/protease
Cancer
[1]Sala G, et al. An ErbB-3 antibody, MP-RM-1, inhibits tumor growth by blocking ligand-dependent and independent activation of ErbB-3/Akt signaling. Oncogene. 2012 Mar 8;31 (10) :1275-86.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P991243/
Inhibitory Antibodies
No Development Reported
Beschrijving
MP-RM-1 is a selective murine monoclonal antibody inhibitor targeting human epidermal growth factor receptor 3 (ErbB-3) . MP-RM-1 blocks the activation of ErbB-
Specificaties
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Box of 180 Label(s)
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Consumable Pack M996039
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